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pentobarbital will decrease the level or outcome of zolpidem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.pentobarbital will decrease the level or result of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration. Potent or average CYP3A induce